Standard Microscopy |
Standard High Content Screening |
Intelligent Screening Approach |
Advantages |
Advantages |
Advantages |
- High quality images
- No empty fields
- Maximum resolution
- Low storage capacity required
|
- Automated acquisition/analysis
- High sample throughput
- Statistically robust information
|
- Events of interest-driven acquisition (any shape allowed, and time and storage saving)
- High sample throughput
- Automated acquisition/analysis (any format allowed)
- Optimal quality images (maximum resolution available)
- No empty fields (easier image analysis)
- Statistically robust information
|
Disadvantages |
Disadvantages |
- User-dependent acquisition
- Small number of samples scanned
- Time consuming
|
- Random sampling (empty fields)
- Robust biological assay required (Z-score)
- Strong image /data analysis required
- Powerful computers required to handle the huge amount of images/data
- Intermediate resolution images or time consuming choice
|